Role of Enzymic Antioxidants in Mediating Oxidative Stress and Contrasting Wound Healing Capabilities in Oral Mucosal/Skin Fibroblasts and Tissues

Unlike skin, oral mucosal wounds are characterized by rapid healing and minimal scarring, attributable to the “enhanced” properties of fibroblasts (OMFs). As oxidative stress is increasingly implicated in regulating wound outcomes, this study compared biomarker enzymic antioxidant profiles between patient-matched mucosal/skin tissues OMFs/skin (SFs) determine whether superior capabilities reduced contributed these preferential properties. Oral mucosa skin exhibited similar patterns protein damage lipid peroxidation, localized within lamina propria/dermis oral/skin epithelia, respectively. SOD1, SOD2, SOD3 catalase were primarily epithelial overall. However, was also widespread propria OMFs, vasculature extracellular matrix. OMFs further identified as being more resistant reactive oxygen species (ROS) generation DNA/protein than SFs. Despite histological evaluation suggesting that possessed higher expression, not fully substantiated for all examined due inter-patient donor variability. Such findings suggest antioxidants have limited roles mediating privileged responses implying other non-enzymic could be involved protecting from